High Density Oligonucleotide Array Fabrication Technology
Key Features
- Overcomes problems associated with photoacid-directed synthesis of high density oligonucleotide arrays.
- One patent near grant in US and EU; another PCT application filed.
- Film polymers identified that permit effective use of weak photogenerated acid, avoiding strong acids or high temperatures.
- Novel intrafilm mechanisms to remove released acid-labile protecting groups.
- Enables deprotection which is rapid (<60s), efficient (>99%), highly light sensitive (60mJcm-2 at 365nm) and effectively irreversible.
